GB/T 19136-2021Testing method of the accelerated storage stability at elevated temperature for pesticides (English PDF)

3.1 Controlled-release formulation

through functional materials or controlled release technology, the formulation that the release of active ingredients is purposely controlled and has a long-lasting effect

3.2 Long lasting

storage bag the storage bag formulation that, through special treatment, the release of active ingredients can be slowed down or controlled, thereby forming physical and chemical control of pests

3.3 Matrix release

the formulation that slows down or controls the release of active ingredients through the polymer matrix, so as to achieve the purpose of sustained long-term effect

4.1 General

Accelerated storage stability test conditions are generally 14 days at 54°C ± 2°C. The test conditions may be changed when the preparation is neither suitable nor intended for use in hot climates, and when high temperatures have a negative effect on the preparation. Alternative conditions are: 50°C±2°C, 4 weeks; 45°C±2°C, 6 weeks; 40°C±2°C, 8 weeks; 35°C±2°C, 12 weeks; 30°C±2°C, 18 weeks.

The sample size of accelerated storage test shall be determined according to the specified items after accelerated storage. Sampling shall be carried out according to the characteristics of different dosage forms.

4.2 Method summary

After storing the specimen at 54°C±2°C for 14 days, measure the specified items.

4.3 Instruments

4.3.1 Thermostat: 54°C±2°C, an explosion-proof thermostat shall be used for the aerosol.

4.3.2 Storage containers shall meet the following conditions:

a) Liquid preparations, powder preparations, granular preparations, long-term mosquito nets and long-term storage bags shall be in screw-top glass bottles with polytetrafluoroethylene seals or original packaging;

b) Aerosols, anti-mosquito nets, dispersing wicks and electric heating mosquito- repellent coils are in original packaging;

c) The matrix releases are packaged in aluminum foil paper or in the original commodity packaging;

d) For other formulations, a storage container or original product packaging that has no effect on the specimen and can be sealed shall be selected.

4.4 Test steps

4.4.1 Liquid, powder and granule formulations

Place the specimen in a glass bottle and seal it. Store in an incubator at 54°C±2°C for 14 d. Take out. Put in a desiccator. Cool to room temperature. Complete the determination of the specified items such as the mass fraction of active ingredients within 24 h.

The accelerated storage test can also be carried out directly using the original package of the commodity.