GB/T 41413-2022Determination of migration of N-nitrosamines and N-nitrosatable substances in toys—High performance liquid chromatography-tandem mass spectrometry (English PDF)
玩具中N-亚硝胺及其前体物迁移量的测定 高效液相色谱-串联质谱法
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Issued by
SAMR; SAC
Level / Type
National · Recommended
Issue date
April 15, 2022
Implementation date
April 15, 2022
Scope
GB/T 41413-2022 is the English-translated version of 玩具中N-亚硝胺及其前体物迁移量的测定 高效液相色谱-串联质谱法.
GB/T 41413-2022 is the Chinese national method for measuring how much of an N-nitrosamine, or of a substance that can be nitrosated into one, migrates out of a toy.
The determination is made by high performance liquid chromatography with tandem mass spectrometry, on elastomeric toys and elastomer toy parts - balloons and gutta-percha are the examples given - and on finger paints.
It covers thirteen N-nitrosamines and their precursors, and other compounds may be determined the same way once the method has been verified.
The document gives the principle, the reagents and materials, the apparatus, sample preparation, the measurement, the calculation, the limits of quantitation, the precision and the test report, and lists the thirteen compounds in a normative annex.
It cites GB/T 6682, was issued on 15 April 2022 and has applied since the same date.
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Document preview — GB/T 41413-2022
National Standard of the People's Republic of China
- ICS
- 97.200.50
- Classification
- Y 57
Issued by: State Administration for Market Regulation; Standardization Administration of the PRC
Contents
- Preface
- 1 Scope
- 2 Normative references
- 3 Terms and Definitions
- 4 Principle
- 5 Reagents and Materials
- 6 Instruments and equipment
- 7 Sample Preparation
- 8 Assay
- 9 Result calculation
- 10 Method Limits of Quantitation
- 11 Precision
- 12 Test report
- Appendix A (informative) Background and rationale for this document
- Appendix B (normative) 13 N-nitrosamines tested in this document
- Appendix C (informative) Total ion chromatogram of 13 N-nitrosamines
- Appendix D (Informative) Precision Test Results
- Reference
Foreword
This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1: Structure and Drafting Rules of Standardization Documents" drafted.
1 Scope
This document describes a high performance liquid chromatography-tandem mass spectrometry method for the determination of the migration of N-nitrosamines and their precursors in the following toys and toy materials Spectrum.
--- Elastomeric toys and toy elastomer parts.
--- Refers to paint.
Example: Elastomeric toys such as balloons and gutta-percha.
Note: For elastomer materials, N-nitrosamines and their precursors are mainly detected in vulcanized materials.
This document is applicable to the determination of the migration of 13 kinds of N-nitrosamines and their precursors in the above toys and toy elastomer materials. other The detection of N-nitrosamines and their precursors can be carried out with reference to this document after verification.
2 Normative references
The contents of the following documents constitute essential provisions of this document through normative references in the text. Among them, dated citations documents, only the version corresponding to that date applies to this document; for undated references, the latest edition (including all amendments) applies to this document.
GB/T 6682 Analysis Laboratory Water Specifications and Test Methods
3 Terms and Definitions
The following terms and definitions apply to this document.
3.1 Finger paint
A clay-like or gel-like coloring material designed to be applied directly to surfaces by children's fingers or hands. [Source: GB 6675.14-2014, 3.1]
3.2 Elastomer
At room temperature, it deforms significantly under the action of force, and after release, it can quickly recover to a flexible cross-linked macromolecule close to its original state and size. sub material.
NOTE: Not all elastomers may contain N-nitrosamines and N-nitrosamine precursors. About N-nitrosamines and N-nitrosamine precursors in elastomers See Appendix A for possible sources and other relevant information. [Source: ENISO 472:2013, 2.327, with modifications]
3.3 N-nitrosamine
It contains -NN=O characteristic functional group, which is usually produced by the reaction of amine and nitrating agent under acidic conditions.
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This preview omits tables, figures, formulas and parts of the technical clauses. The complete document — 18 pages — is available in the English PDF.
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