GB/T 28236-2011Method of chromosome aberration analysis for biological dose assessment (English PDF)
染色体畸变估算生物剂量方法
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Issued by
SAMR; SAC
Level / Type
National · Recommended
Issue date
December 30, 2011
Implementation date
May 1, 2012
Scope
GB/T 28236-2011 is the English-translated version of 染色体畸变估算生物剂量方法.
GB/T 28236-2011 is the Chinese standard "Method of chromosome aberration analysis for biological dose assessment". Its scope clause reads: This standard gives a dose of ionizing radiation-induced chromosomal aberrations in human peripheral blood lymphocytes - established with effect curve and estimate its students It was dose approach.
This standard applies to a relatively homogeneous body external irradiation dose by accident according to staff estimates. This standard also applies to cases of a uniform dose of external radiation and burn body estimates.
This standard does not apply to fractionated irradiation, the cumulative long-term low-dose radiation and internal radiation biological dose estimation. Its clauses include terms and definitions.
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Document preview — GB/T 28236-2011
National Standard of the People's Republic of China
- ICS
- 13.100
- Classification
- C 60
Issued by: State Administration for Market Regulation; Standardization Administration of the PRC
Contents
- 1 Scope
- 2 Terms and definitions
- 2.1 Biological dosimeter
- 2.2 Dose - effect curve dose-responsecurve
- 2.3 Chromosome
- 2.4 Chromosome aberrations
- 2.5 Chromosome aberrations
- 2.6 Chromatid aberrations
- 2.7 Unstable chromosome aberrations
1 Scope
This standard gives a dose of ionizing radiation-induced chromosomal aberrations in human peripheral blood lymphocytes - established with effect curve and estimate its students
It was dose approach.
This standard applies to a relatively homogeneous body external irradiation dose by accident according to staff estimates.
This standard also applies to cases of a uniform dose of external radiation and burn body estimates.
This standard does not apply to fractionated irradiation, the cumulative long-term low-dose radiation and internal radiation biological dose estimation.
2 Terms and definitions
The following terms and definitions apply to this standard.
2.1 Biological dosimeter
To estimate radiation dose of biological systems, there is a certain clearance between the quantitative reaction of the biological system by irradiation with radiation dose
Department, which can be used for estimating radiation doses.
2.2 Dose - effect curve dose-responsecurve
A substance or biological system by the presence of some kind of quantitative relationship between radiation dose and the response after irradiation, can be fitted to both fitness
When the mathematical models, and prepare the corresponding scale curve, called the dose - response curve, which can be used to estimate radiation doses.
2.3 Chromosome
Vector genes. Present in the nucleus when cells divide, under the effect of colored basic dye darker. The DNA (DNA), a small amount of protein and ribonucleic acid (RNA) components.
2.4 Chromosome aberrations
The number of normal and abnormal structure of chromosomes in the factors of physical, chemical or biological on.
2.5 Chromosome aberrations
Irradiation in Go or G1 phase of the cell, since before DNA synthesis, a single chromosome to the exercise of its function, then induced
Distortion, after S phase replication, involves the formation of two single chromosomal aberrations, including non-centromeric fragments, small body, no centromere
Ring, ring centromere, centromere or double body, inversions, translocations, insertions and deletions and the like.
2.6 Chromatid aberrations
Most cells in the S phase and G2 phase irradiated cells according to the subject, has been subjected to DNA synthesis, already formed two separate monomers. The
In only induced chromatid aberrations, including chromatid breaks, chromatid exchange, and the like chromatid chromatid gap and gap.
2.7 Unstable chromosome aberrations
Unstable chromosome aberrations including non-centromeric fragments, small body, no centromere rings, dicentric ring body and the centromere.
No centromere fragments, small body, no centromere ring, because no centromere on the spindle orientation can not be quickly lost from the dividing cells.
Dicentric ring body and the centromere is often formed during anaphase chromosome bridge or tetraploid and often lead to cell death caused by the above five abnormal
END: Draft Version (GB/T 28236-2011)
GBZ 20-2019 | GBZ 57-2019 | GB/T 31989-2015 | GB/T 51453-2024 | GB/T 39791.4-2024 | GB/T 16180-2014 |
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This preview omits tables, figures, formulas and parts of the technical clauses. The complete document — 15 pages — is available in the English PDF.
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