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GB/T 21765-2025Chemicals - Test method of subchronic inhalation toxicity (English PDF)

化学品 亚慢性吸入毒性试验方法

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Issued by

SAMR; SAC

Level / Type

National · Recommended

Issue date

October 5, 2025

Implementation date

February 1, 2026

Scope

GB/T 21765-2025 is the English-translated version of 化学品 亚慢性吸入毒性试验方法.

GB/T 21765-2025 is the Chinese standard "Chemicals - Test method of subchronic inhalation toxicity". Its scope clause reads: This document specifies the basic principles, test methods, test data, and reporting for the subchronic inhalation toxicity testing of chemicals.

This document applies to the detection of subchronic inhalation toxicity of chemicals (including nanomaterials). Its clauses include terms and definitions; abbreviations.

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Document preview — GB/T 21765-2025

National Standard of the People's Republic of China

ICS
13.300
Classification
A 80
Replacing
GB/T 21765-2008

Issued by: State Administration for Market Regulation; Standardization Administration of the PRC

Contents

  • Foreword
  • Appendix A and Appendix B (4.4,.2008 edition);
  • 6.9.6, 6.9.7, and 4.9 (2008 edition).

1 Scope

This document specifies the basic principles, test methods, test data, and reporting for the subchronic inhalation toxicity testing of chemicals.

This document applies to the detection of subchronic inhalation toxicity of chemicals (including nanomaterials).

2 Normative references

The contents of the following documents, through normative references within the text, constitute essential provisions of this document. Dated citations are not included.

For references to documents, only the version corresponding to that date applies to this document; for undated references, the latest version (including all amendments) applies.

This document.

GB 14925 Laboratory Animal Environment and Facilities

3 Terms and Definitions

The following terms and definitions apply to this document.

3.1

The harmful effects that occur when experimental animals repeatedly inhale the test substance continuously (approximately 1/10 of their lifespan).

3.2 Elimination kinetics

The ways and rates at which chemicals are eliminated from the body.

4 Abbreviations

The following abbreviations apply to this document.

PEO. Post-Exposure Observation 5.1 Experimental animals were exposed to different concentrations of the test substance daily for 6 hours over a 90-day period. It is advisable to have 3 or more concentration groups.

Five animals were included in each of the following groups. a negative control group (filtered air) and a solvent control group. Five male and five female animals were included in each group. Animals were observed daily during the exposure period.

GB/T 21617 | GB 23350 | GB/T 21622 | GB/T 21763 | GB/T 21759 | […]

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This preview omits tables, figures, formulas and parts of the technical clauses. The complete document — 30 pages — is available in the English PDF.

Referenced standards

Editions of GB/T 21765

EditionTitleRevisionStatus
GB/T 21765-2025Chemicals - Test method of subchronic inhalation toxicitycurrent editionCurrent
GB/T 21765-2008Chemicals -- Test method of sub-chronic inhalation toxicity studyprevious editionIn force

This page sells the current edition, GB/T 21765-2025. Earlier editions are listed for reference only.

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