GB/T 21754-2025Chemicals — Test method of 28 day (subacute) inhalation toxicity (English PDF)

Foreword

This document complies with the provisions of GB/T 1.1-2020 "Standardization Work Guidelines Part 1: Structure and Drafting Rules of Standardization Documents". Drafting.

This document supersedes GB/T 21754-2008 "Test Method for Inhalation Toxicity of Chemicals with Repeated Dose over 28 Days/14 Days" and is consistent with GB/T Compared to 2008, aside from structural adjustments and editorial changes, the main technical changes are as follows.

— The scope has been changed (see Chapter 1, Chapter 1 of the 2008 edition);

— Terminology and Definitions, Abbreviations have been revised (see Chapters 3 and 4, Chapter 2 of the 2008 edition);

— The "Test Methods" section has been revised, and "Dose Exploration Trials" has been added (see Chapter 6, Chapter 4 of the 2008 edition);

— The "Test Method" has been modified, including the mass median aerodynamic diameter (MMAD) and geometric standard deviation of particulate aerosols.

(GSD) requirements (see Chapter 6, 6.7, 4.4.2 of the 2008 edition);

— The "Test Methods" have been modified to include the detection and analysis of bronchoalveolar lavage fluid and lung load, as well as pathological examination of lung tissue (see section [number]).

Chapter 6, 6.8 (4.4.1 in the 2008 edition);

— An "Appendix A Test Protocol" has been added (see Appendix A).

Please note that some content in this document may involve patents. The issuing organization of this document assumes no responsibility for identifying patents.

This document was proposed and is under the jurisdiction of the National Technical Committee on Standardization of Hazardous Chemicals Management (SAC/TC251).

This document was drafted by. the National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention; Guangdong Provincial Institute of Occupational Disease Prevention and Control; and Ningde Municipal Standard Standardization Association.

The main drafters of this document are: Liu Lili, Xie Zhiwei, Zeng Lihai, Lu Fengrong, Li Bin, Chen Xiao, Xiao Jingwei, Zhang Yi, Yu Tao, and Lin Liwei.

The release history of this document and the document it replaces is as follows.

— First published in 2008 as GB/T 21754-2008;

— This is the first revision. Chemicals, 28 days (subacute) Inhalation toxicity test method

1 Scope

This document describes the test method for the 28-day (subacute) inhalation toxicity of chemicals.

This document applies to 28-day (subacute) inhalation toxicity testing of chemicals.

2 Normative references

GB 14925

3 Terms and Definitions

The following terms and definitions apply to this document.

4 Abbreviations

The following abbreviations apply to this document.