GB/T 21605-2025Chemicals — Test method of acute inhalation toxicity (English PDF)

Foreword

This document complies with the provisions of GB/T 1.1-2020 "Standardization Work Guidelines Part 1: Structure and Drafting Rules of Standardization Documents". Drafting.

This document supersedes GB/T 21605-2008 "Test Methods for Acute Inhalation Toxicity of Chemicals" and is consistent with GB/T 21605-2008.

Aside from structural adjustments and editorial changes, the main technical changes are as follows.

— The chapter on "Scope" has been revised (see Chapter 1, Chapter 1 of the 2008 edition);

— Terminology and definitions have been revised (see Chapter 3, Chapter 2 of the 2008 edition);

— Added evaluation of whether the test substance can be absorbed through the respiratory tract (see Chapter 4);

— Added the principles of pre-experiment data collection and analysis, and the traditional LC50 method and concentration-time method (see Chapter 5);

— Added exposure condition monitoring (see 6.6), removed the static exposure method (see 5.3.1 in the 2008 version), and changed the dynamic exposure method.

Compared to the traditional LC50 method and concentration-time method (see 6.7, 5.3.2 in the 2008 edition), clinical observation, weight monitoring, and pathological studies have been added. Check (see 6.8);

— The section on "Experimental Data and Reporting" has been revised (see Chapter 7, 5.5, Chapter 6, and Chapter 7 of the 2008 edition);

— A "concentration-time method" has been added (see Appendix A).

Please note that some content in this document may involve patents. The issuing organization of this document assumes no responsibility for identifying patents.

This document was proposed and is under the jurisdiction of the National Technical Committee on Standardization of Hazardous Chemicals Management (SAC/TC251).

This document was drafted by: Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention; Guangdong Provincial Institute of Occupational Disease Prevention and Control; and Fujian Ningjia.

Jun Testing Technology Service Co., Ltd.

The main drafters of this document are: Liu Lili, Zeng Lihai, Zhang Yi, Xie Zhiwei, Zheng Jiewei, Li Bin, Chen Xiao, Xiao Jingwei, Yu Tao, and Zhang Huaxin.

The release history of this document and the document it replaces is as follows.

— First published in 2008 as GB/T 21605-2008;

— This is the first revision.

1 Scope

This document describes the methods for testing the acute inhalation toxicity of chemicals.

This document applies to acute inhalation toxicity testing of chemicals.

2 Normative references

GB 14925

3 Terms and Definitions

The following definitions and terms apply to this document.