GB/T 15670.9-2017Toxicological test methods for pesticides registration—Part 9: Skin sensitisation test (English PDF)

Foreword

GB/T 15670 "pesticide registration toxicology test method" is divided into the following sections.

--- Part 1. General principles;

--- Part 2. Acute oral toxicity test Horn's method;

--- Part 3. Acute oral toxicity test sequential method;

--- Part 4. Acute oral toxicity test probability unit method;

--- Part 5. Acute dermal toxicity test;

--- Part 6. Acute inhalation toxicity test;

--- Part 7. Skin irritation/corrosivity test;

--- Part 8. Acute eye irritation/corrosiveness test;

--- Part 9. Skin allergy (sensitization) test;

--- Part 10. Short-term repeated oral toxicity (28 days) toxicity test;

--- Part 11. Short-term repeated transdermal (28 days) toxicity test;

--- Part 12. Short-term repeated inhalation exposure (28 days) toxicity test;

--- Part 13. Subchronic toxicity test;

--- Part 14. bacterial recovery mutation test;

--- Part 15. In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test;

--- Part 16. In vivo mammalian bone marrow cell chromosome aberration test;

--- Part 17. Mammalian spermatogonial/spermatocyte chromosome aberration test;

--- Part 18. Rodent dominant lethality test;

--- Part 19. In vitro mammalian chromosome aberration test;

--- Part 20. In vitro mammalian cell gene mutation test;

--- Part 21. In vivo mammalian hepatocyte extracellular DNA synthesis (UDS) test;

--- Part 22. DNA damage and repair in vitro mammalian cells/DNA synthesis test outside the program;

--- Part 23. Teratogenicity test;

--- Part 24. Two generations of reproductive toxicity test;

--- Part 25. Acute delayed neurotoxicity test;

--- Part 26. Chronic toxicity test;

--- Part 27. Carcinogenicity test;

--- Part 28. Chronic toxicity and carcinogenicity combined test;

--- Part 29. Metabolism and toxicokinetic tests.

This section GB/T 15670 Part 9.

This section drafted in accordance with GB/T 1.1-2009 given rules.

Part of this section instead of GB/T 15670-1995 "pesticide registration toxicology test methods."

This section and the GB/T 15670-1995 skin allergy (sensitization) test section compared to the main changes are as follows.

--- Modify and adjust the standard of the overall structure and layout format;

--- Added some chapters (see Chapter 1, Chapter 2, Chapter 3, Chapter 5, 6.1, 6.2, 6.3.3.4, 6.3.3.6, 6.4, 6.5 and Chapter 7);

--- Modify the requirements for experimental animals (see 6.3.1, 1995 edition 7.3);

--- Modify the requirements for the setting of positive and negative controls (see 6.3.5.5, 1995 edition 7.5.2);

--- Modify the results of the assessment (see 6.3.4, 1995 version 7.6);

--- Increased guinea pig maximum test and mouse lymph node analysis test two test methods (see 6.4,6.5).

1 Scope

This section GB/T 15670 specifies the skin allergy (sensitization) test the basic principles, methods and requirements.

This section applies to the registration of pesticides for skin allergy (sensitization) test.

2 Normative references

The following documents for the application of this document is essential. For dated references, only the dated version applies to this document. For undated references, the latest edition (including all amendments) applies to this document.

GB 14925 laboratory animal environment and facilities

3 Terms and definitions

The following terms and definitions apply to this document.

4 Test purposes

Determine whether repeated exposure to test substances can cause skin allergies in mammals and their extent.