GB/Z 134-2026Surface chemical analysis - Characterization of functional glass substrates for biosensing applications (English PDF)

1 Scope

This document provides examples of surface chemical analyses within the scope of ISO /TC201 that are helpful in characterizing the properties of substrates used in the production of biosensors.

Analytical methods. Successful characterization allows for a better understanding of the surface chemical reactions at each step of the production process, and these properties will affect...

The overall performance of the final device (such as a microarray). The fabrication steps include immobilization of linker molecules for substrate activation, and the use of biosensors (i.e., the...)

The so-called probe requires specific biomolecules to functionalize the activated substrate.

Silyl functionalization of glass slides is a key focus of research on biosensing glass substrates and a crucial production step for subsequent immobilization of probe molecules.

The fixed probes are used to sense biometric events. The silanization process was chosen because it is currently the most popular process in biosensor manufacturing.

One of the methods.

This document outlines the identification of the substrate, device manufacturing steps (such as cleaning, activation, and chemical modification), and shelf life (such as storage conditions and aging).

Methods, strategies, and guidelines regarding potential sources of problems. These are relevant for surface chemical analysts and biotransmitters characterizing glass-substrate biosensors.

This is particularly relevant for developers or quality managers in the field of sensor manufacturing. Based on quantitative and qualitative surface chemical analysis, strategies can be developed to

Identify the causes of poor performance during device manufacturing and implement corrective measures. This document demonstrates the current level of research in this technology and ISO /TC201.

This could be a potential starting point for more specific work in the future, which will eventually lead to standardized measurement procedures.

This document does not discuss specific solutions. For more information on solutions, please refer to relevant professional literature, such as the references.

References [1] to [9].

2 Normative references

The contents of the following documents, through normative references within the text, constitute essential provisions of this document. Dated citations are not included.

For references to documents, only the version corresponding to that date applies to this document; for undated references, the latest version (including all amendments) applies.

This document.

ISO 18115-1.2013 Surface chemical analysis vocabulary - Part 1.General terminology and spectroscopic terminology (Surfacechemical)

Note. GB/T 22461.1-2023 Surface Chemical Analysis Vocabulary Part 1.General Terminology and Spectroscopic Terminology (ISO 18115-1.2013, IDT)

ISO 18115-2.2013 Surface chemical analysis vocabulary - Part 2.Scanning probe microscopy terminology (Surfacechemical)

Note. GB/T 22461.2-2023 Surface Chemical Analysis Vocabulary Part 2.Scanning Probe Microscopy Terminology (ISO 18115-2.2021, MOD)

3 Terms and Definitions

The terms and definitions defined in ISO 18115-1.2013 and ISO 18115-2.2013 apply to this document.

4 Symbols and Abbreviations

The following symbols and abbreviations apply to this document.