GB/T 39650-2020Laboratory animal—Rules for nomenclature of mouse and rat strains (English PDF)

1 Scope

This standard specifies the naming rules for experimental animal mouse and rat strains, including the genetic classification of experimental animals, laboratory codes, and inbreeding

Lines, multiple source inbred lines, homologous mutant inbred lines, homologous introduction inbred lines and isolated inbred lines, closed group (outbred group) and hybrid group

Naming:

This standard applies to the naming of experimental animal mouse and rat strains:

2 Normative references

The following documents are indispensable for the application of this document: For dated reference documents, only the dated version applies to this article

Pieces: For undated references, the latest version (including all amendments) applies to this document:

GB 14923 Laboratory Animals Genetic Quality Control of Mammals Laboratory Animals

3 Terms and definitions

The following terms and definitions defined in GB 14923 apply to this document:

3:1

Segregatinginbredstrains

Through inbred breeding (usually sibling mating), each generation performs heterozygosity screening to isolate inbred lines to make a specific allele or mutation

An inbred line that remains heterozygous:

3:2

Colaborative crossstrains; CC; GC Contains from 8 progenitor lines (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZ/HILtJ, CAST/EiJ, PWK/

PhJ and WSB/EiJ) genetic genes: The funnel breeding strategy is adopted to incorporate all 8 ancestral lines into 3 breeding populations, and successive generations of brothers

A multi-parental recombinant inbred line derived from the mating of sisters:

4 Classification of laboratory animal genetics

According to the different breeding methods and genetic characteristics of experimental animals, the classification is as follows:

a) Inbred strains:

1) Recombinantinbredstrains, RI;

2) Recombinant congenicstrains, RC;

3) Colaborative crossstrains, CC, GC;

4) Mixed systems mixedinbredstrains, MI;

5) Advanced intercrosslines, AIL;

6) Homologous mutation inbred lines coisogenicinbredstrains;

7) Homologous introduction of inbred lines (same inbred lines) congenicinbredstrains;

8) Chromosome substitution system consomicstrainsorchromosomesubstitutionstrains;