GB/T 29637-2023Examination methods for ketamine in suspected drugs (English PDF)

Foreword

This document complies with the provisions of GB/T 1.1-2020 "Standardization Work Guidelines Part 1: Structure and Drafting Rules of Standardization Documents" Drafting.

This document replaces GB/T 29637-2013 "Gas Chromatography and Gas Chromatography-Mass Spectrometry Test Methods for Ketamine in Suspected Drugs" and is consistent with Compared with GB/T 29637-2013, in addition to structural adjustments and editorial changes, the main technical changes are as follows:

---Changed the "scope" (see Chapter 1, Chapter 1 of the 2013 edition);

---Deleted the principle of gas chromatography method (see Chapter 4 of the 2013 edition);

---Added the principles of liquid chromatography and liquid chromatography-mass spectrometry methods (see Chapter 4);

---Deleted gas chromatography analysis reagents and reference materials, instruments and measuring instruments (see Chapter 5 of the 2013 edition);

--- Added reagents, instruments and materials for liquid chromatography and liquid chromatography-mass spectrometry (see Chapter 5);

---Changed the mass concentration of the gas chromatography-mass spectrometry qualitative quality control standard working solution (see 5.1.1.6, 6.1 of the 2013 version);

---Added liquid chromatography and liquid chromatography-mass spectrometry qualitative analysis (see 6.1.2 and 6.2);

---Deleted gas chromatography quantitative analysis (see Chapter 7 of the 2013 edition);

---Added liquid chromatography quantitative analysis (see Chapter 7);

---Changed the result evaluation (see Chapter 8, Chapter 8 of the 2013 edition).

1 Scope

This document describes the gas chromatography-mass spectrometry (GC-MS), liquid chromatography (LC), and liquid chromatography-mass spectrometry (LC-MS) qualitative testing of ketamine.

Principles, reagents, instruments and materials, test analysis steps and result evaluation of test methods and liquid chromatography (LC) quantitative test methods.

This document is suitable for qualitative and quantitative analysis of ketamine in suspected drugs.

2 Normative reference documents

The contents of the following documents constitute essential provisions of this document through normative references in the text. Among them, the dated quotations For undated referenced documents, only the version corresponding to that date applies to this document; for undated referenced documents, the latest version (including all amendments) applies to this document.

GB/T 6682 Specifications and test methods for water used in analytical laboratories

GB/T 27418 Evaluation and expression of measurement uncertainty

GA/T 122 Toxicological analysis terminology

3 Terms and definitions

The terms and definitions defined in GA/T 122 apply to this document.

4 Principles

Extract ketamine from suspected drugs (see Appendix A for basic information on ketamine). using gas chromatography-mass spectrometry and liquid chromatography Method detection, based on gas chromatography-mass spectrometry retention time, mass spectrometry characteristic ions, ion abundance ratio and liquid chromatography retention time as the basis for qualitative judgment According to the data; liquid chromatography-mass spectrometry is used for detection, and the retention time, mass spectrum characteristic ion pair and ion pair abundance ratio are used as the basis for qualitative judgment; using For liquid chromatography detection, the chromatographic peak area is used as the quantitative basis, and the external standard single point method or the external standard standard curve method is used for quantitative analysis.

5 Reagents, instruments and materials