GB/T 43240-2023Examination methods for 55 drugs and metabolites in hair samples—Liquid chromatography-mass spectrometry (English PDF)

Foreword

This document complies with the provisions of GB/T 1.1-2020 "Standardization Work Guidelines Part 1: Structure and Drafting Rules of Standardization Documents" Drafting.

1 Scope

This document describes the qualitative and quantitative liquid chromatography-mass spectrometry (LC-MS) testing of 55 drugs of abuse and their metabolites in human hair. method.

This document is applicable to the qualitative analysis and quantitative analysis of 55 drugs of abuse and metabolites in human hair.

2 Normative reference documents

The contents of the following documents constitute essential provisions of this document through normative references in the text. Among them, the dated quotations For undated referenced documents, only the version corresponding to that date applies to this document; for undated referenced documents, the latest version (including all amendments) applies to this document.

GB/T 6682 Specifications and test methods for water used in analytical laboratories

GA/T 122 Toxicological analysis terminology

3 Terms and definitions

The terms and definitions defined in GA/T 122 apply to this document.

4 Principles

Using blank samples and added samples as controls, according to the requirements of parallel operations, 55 kinds of abused drugs including methamphetamine and their metabolism in hair were analyzed.

Objects (see Appendix A for specific information) for extraction. Liquid chromatography-mass spectrometry is used for detection, with retention time, mass spectrum characteristic ion transitions and ion transitions The abundance ratio is used as the basis for qualitative judgment; the chromatographic peak area (or peak area ratio) is used as the quantitative basis, and the external standard method or the internal standard method is used for quantification. analyze.

5 Reagents and materials