GB/T 39768-2021Classification and coding for human biomaterial (English PDF)

3.1 Human biomaterial

Any substance obtained or derived from the human body, including but not limited to tissue, blood, urine, skin, bone marrow, muscle, hair, secretions and internal Organs, etc.

3.2 Typeofhumanbiomaterial

According to the common characteristics and morphology of biological samples, the types of biological samples are divided, which can be divided into tissues, blood, semen, secretions, Cell suspension, excrement, cells or processed biological samples (DNA, RNA, protein, etc.), and other biological materials, etc.

3.3 Whole blood

Collect human peripheral blood into a mixture formed in a blood collection tube/bag with an appropriate amount of anticoagulant.

Note: All blood components including blood cells and plasma.

3.4 General biomaterial

Physical specimens are complete organs or organisms as opposed to sliced samples.

Example: Such as a human brain or embryo sample soaked in formalin.

3.5 Circulating-freecelDNA; cf-DNA

The extracellular DNA present in body fluids such as plasma or serum is referred to as free DNA.

Note: Extracellular DNA is also called circulating DNA or cell-free DNA.

3.6 Circulating tumor DNA; ct-DNA

Necrotic or apoptotic tumor cells with tumor-specific mutations or epigenetic changes, which are contained in free DNA (cf-DNA)

Tumor DNA fragments released into the peripheral blood are referred to as circulating tumor DNA.

Note: Part of cf-DNA in tumor patients.