GB 22622-2008Propamocarb hydrochloride aqueous solution (English PDF)

Foreword

The standard Chapter 3, Chapter 5 are mandatory, the rest are recommended.

Appendix A of this standard is an informative annex.

The standard proposed by China Petroleum and Chemical Industry Association.

This standard by the National Standardization Technical Committee on Pesticides (SAC/TC133) centralized.

2 Normative references

The following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard.

Determination of GB/T 1601 Pesticides pH value GB/T 1604 Goods pesticide regulations for acceptance GB/T 1605-2001 Sampling Method commercial pesticides GB 3796 pesticide packaging General GB/T 4472 chemical product density, relative density measurement General GB/T 19137-2003 Pesticide cryogenic stability Determination 19136-2003 Thermal storage stability of pesticides GB/T Determination

3 Requirements

3.1 Composition and appearance. This product should be compliant propamocarb (hydrochloride) original drug or propamocarb hydrochloride parent drug is made, the appearance of a homogeneous liquid Body, no obvious suspended solids and sediments.

3.2 propamocarb hydrochloride salt water should meet the requirements of Table 1.

Table 1 propamocarb hydrochloride salt water control project indicators

project

index

722g/L 35.0%

Propamocarb hydrochloride salt mass fraction a /% 66.5 ± 2.5 35.0 ± 1.8 Propamocarb hydrochloride concentration (20 °C) / (g/L) 722 ± 25 -Water-insoluble mass fraction /% <= 0.3 pH range of 3.0 to 7.0 Dilution stability (diluted 20 times) Qualified Low temperature stability b a qualified Thermal storage stability b a qualified when a dispute arises when quality to propamocarb mass fraction of arbitration.

b low temperature stability, thermal storage stability test under normal production conditions, every 3 months test at least once.

Test Method 4

5 Marking, labeling, packaging, storage and transportation

Label 5.1 propamocarb hydrochloride salt agent shall indicate the mass fraction of propamocarb hydrochloride.

Flag 5.2 propamocarb hydrochloride salt agent, labeling and packaging should comply with the provisions of GB 3796.

5.3 propamocarb hydrochloride salt water available within the plug and cover with a polyester bottle, net content of 200mL, 1000mL etc; outsourcing Fitted with corrugated boxes or plastic boxes, each containing a net capacity not exceeding 20000mL. Also available upon request or order agreement, the use of other forms of Packaging, but to comply with the provisions of GB 3796.

5.4 propamocarb hydrochloride salt water package should be stored in ventilated, dry warehouse, stacked manner consistent with safe, convenient handling principles.

5.5 storage, prevent moisture and sunlight, to avoid infiltration of ground; no food, beverages, animal feed-mixing; avoid contact with skin, eye contact Touch, mouth and nose to prevent inhalation.

5.6 Security. propamocarb hydrochloride salt water is a toxic fungicide harmful. When used, should wear protective gloves, masks, wear dry Net protective clothing immediately after use with soap and water. The agent contact with skin, wash immediately with soap and water; if splashed into the eyes, should Rinse immediately with plenty of water; consult a doctor if necessary. If swallowed, do not induce vomiting, consult a doctor, mouth and drink plenty of water, clothes Activated carbon.

5.7 Warranty. Under the provisions of storage and transportation conditions, warranties of propamocarb hydrochloride salt agent two years from date of manufacture.

Appendix A

(Informative)

Methods (CIPAC method) was measured by liquid chromatography propamocarb hydrochloride salt mass fraction A. 1 Method summary + Water sample was dissolved in methanol, + water + ammonia water as the mobile phase, to use as a filler Si100 stainless steel column and ultraviolet detection Detector, sample the propamocarb hydrochloride HPLC separation and determination.

A. 2 Reagents and solutions Methanol. HPLC grade;

Water. The new secondary steam distilled water;

Ammonia solution. 25% (mass fraction);

A mixed solution. [Psi] (methanol. water) = 80.20;

Propamocarb hydrochloride (propamocarb) standard. a known mass fraction >=99.0%.

A. 3 Instrument

LC. a variable wavelength UV detector and quantitative injection valve;

Chromatographic data processor or chromatography workstation;

Column. LichrosorbSi100,250mm × 4mm (. I.d), 5µm stainless steel column (column or other equivalent effect);

Filter. pore size of about 0.45µm;

Micro injector. 50µL.

A. 4 HPLC operating conditions Mobile phase. [Psi] (methanol. water. aqueous ammonia) = 800.192.8;

The mobile phase flow rate. 1.0mL/min;

Column temperature. room temperature (temperature change should not exceed 2 °C);

Detection wavelength. 210nm;

Injection volume. 10µL;

Retention time. propamocarb about 7.4min.

HPLC operating conditions described above, the Department of typical operating parameters. According to the characteristics of different instruments, given operating parameters adjusted as appropriate, in order to obtain the best results. Typical liquid chromatography is shown in Figure propamocarb hydrochloride salt agent A. 1.

1 --- propamocarb.

Figure A. Figure 1 HPLC propamocarb hydrochloride salt agent

A. 5 measuring step

A. 5.1 preparation of standard solution Accurately weigh approximately 0.175g (accurate to 0.0002g) of propamocarb hydrochloride standard sample in 100mL volumetric flask, dissolved with a mixed solution Solution, and set the volume to the mark, shake spare.

A. 5.2 Sample preparation solution Accurately weighed sample containing about taking propamocarb hydrochloride 0.2g (accurate to 0.0002g), and placed in 100mL flask, with a mixed solution Dissolve and dilute to the mark, shake spare. Through 0.45µm membrane filter and set aside.

A. 5.3 Determination Under the above chromatographic operating conditions, after the instrument is stable, continuous injection of several doses of the standard solution until the two adjacent needles propamocarb relative peak area After the change of less than 1.5%, according to the solution, sample solution, sample solution, standard order of standard solution was measured.

A. 6 Calculation

The two doses of the standard solution of two injections of the sample solution and measured before and after the sample solution propamocarb peak areas are averaged. Cream sample the mass fraction of propamocarb hydrochloride 1 (%) according to equation (A.1) (standard when propamocarb hydrochloride) or formula (A.2) (standard of propamocarb time) were Calculate the mass concentration rho propamocarb hydrochloride (g/L) according to formula (A.3) calculated as follows.

Where.

A1 --- the standard solution, the average propamocarb peak area;

A2 --- sample solution, the average propamocarb peak area;

224.7 --- molecular weight propamocarb hydrochloride;

188.3 --- propamocarb molecular weight;

--- Standard samples propamocarb (propamocarb hydrochloride) mass fraction, expressed as a percentage;

A. 7 allowable difference the relative deviation of two parallel determination results shall not be greater than ± 2%, whichever is the arithmetic mean as a measurement result.