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GB 1903.81-2025National food safety standard - Food nutrition fortifier - Vitamin K2 (synthesis method) (English PDF)

食品安全国家标准 食品营养强化剂 维生素K2(合成法)

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Issued by

SAMR; SAC

Level / Type

National · Mandatory

Issue date

September 2, 2025

Implementation date

March 2, 2026

Scope

GB 1903.81-2025 is the English-translated version of 食品安全国家标准 食品营养强化剂 维生素K2(合成法).

GB 1903.81-2025 is a mandatory national food safety standard for synthetic vitamin K2 as a nutritional fortifier. Vitamin K2 has moved from obscurity to prominence because of what it does after vitamin D has done its work: D increases the absorption of calcium, and K2 activates the proteins that direct that calcium into bone rather than leaving it to deposit in arterial walls. It appears now in bone health supplements, dairy products and formulated foods. Synthesising it rather than extracting it from fermentation gives control over the isomer produced - the biologically active form is a specific geometric isomer, and the inactive isomer is not merely useless but a contaminant that inflates any assay that does not distinguish them, so the specification has to. This standard applies to vitamin K2 as a food nutrition fortifier, chemically synthesised from vitamin K3 with a terpene alcohol, or from vitamin K3 with farnesol and geraniol. As a GB it is compulsory. It is written for vitamin manufacturers, for the supplement, dairy and formulated food producers using it, and for the authorities enforcing what may be added to food in China.

Document preview — GB 1903.81-2025

National Standard of the People's Republic of China

Issued by: State Administration for Market Regulation; Standardization Administration of the PRC

Contents

  • 1 Scope3
  • 2 Chemical name, molecular formula, structural formula, and relative molecular mass3
  • 3 Technical requirements3
  • Appendix A Test methods5
  • Appendix B Vitamin K2 (MK-7) liquid chromatogram11

Foreword

2 Chemical name, molecular formula, structural formula, and relative molecular mass 2.1 Chemical name

(all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione

1 Scope

This standard applies to vitamin K2, a food fortifier, which is chemically synthesized

from vitamin K3 and 7-en-terpen-ol, or from vitamin K3, farnesol, and geraniol.

2 Chemical name, molecular formula, structural formula, and

relative molecular mass

2.1 Chemical name

(all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-

methyl-1,4-naphthalenedione

2.2 Molecular formula

2.3 Structural formula

2.4 Relative molecular mass

649.02 (based on the international relative atomic mass in 2022).

Remaining clauses in the full document

  • 3 Technical requirements
  • 3.1 Sensory requirements

......
This preview omits tables, figures, formulas and parts of the technical clauses. The complete document — 15 pages — is available in the English PDF.

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