GB 1886.354-2021National Food Safety Standard - Food Additive - 3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide (English PDF)
食品安全国家标准 食品添加剂 3-[(4-氨基-2,2-二氧-1H-2,1,3-苯并噻二嗪-5-基)氧]-2,2-二甲基-N-丙基丙酰胺
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Issued by
National Health Commission; State Administration for Market Regulation
Level / Type
National · Mandatory
Issue date
August 4, 2021
Implementation date
February 4, 2022
Scope
GB 1886.354-2021 is the English-translated version of 食品安全国家标准 食品添加剂 3-[(4-氨基-2,2-二氧-1H-2,1,3-苯并噻二嗪-5-基)氧]-2,2-二甲基-N-丙基丙酰胺.
GB 1886.354-2021 is the Chinese national food safety standard for the food additive 3-[(4-amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide.
It applies to the additive prepared by chemical reaction from 3-hydroxy-2,2-dimethylpropionic acid, propylamine, 2-amino-6-fluorobenzonitrile and sulfamoyl chloride.
It gives the chemical name, the molecular formula C15H22N4O4S, the structural formula and the relative molecular mass 354.42, and it sets the technical requirements of the product.
Appendix A carries the determination of the content by ultra-high performance liquid chromatography with a diode array detector, on a C18 column of 100 mm length and 4.6 mm inner diameter, with a mobile phase of 0.1% formic acid solution and acetonitrile at 8:2, a column temperature of 25 degrees C and detection at 230 nm. It was issued on 4 August 2021 and has applied since 4 February 2022.
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Document preview — GB 1886.354-2021
National Standard of the People's Republic of China
Issued by: National Health Commission; State Administration for Market Regulation
Contents
- 1 Scope3
- 2 Chemical name, molecular formula, structural formula, and relative molecular mass3
- 3 Technical requirements4
- Appendix A Determination of content of 3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide5
1 Scope
This Standard applies to the food additive 3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide prepared by chemical reaction with 3-hydroxy-2,2-dimethylpropionic acid, propylamine, 2-amino-6-fluorobenzonitrile and sulfamoyl chloride as raw materials.
2 Chemical name, molecular formula, structural formula, and relative molecular mass
2.1 Chemical name
3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide
2.2 Molecular formula
C15H22N4O4S
2.3 Structural formula
2.4 Relative molecular mass
354.42 (according to 2018 international relative atomic mass)
Appendix A Determination of content of 3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide
A.1 Reagents and materials
A.1.1 Formic acid: Chromatographically pure.
A.1.1.1 0.1% formic acid solution: Pipette 1.00 mL of formic acid (A.1.1) into a 1000 mL volumetric flask; add water (A.1.3) to dilute to make up to volume and shake well.
A.1.1.2 0.5% formic acid solution: Pipette 5.00 mL of formic acid (A.1.1) into a 1000 mL volumetric flask; add water (A.1.3) to dilute to make up to volume and shake well.
A.1.2 Acetonitrile: Chromatographically pure.
A.1.3 Water: Grade 1 water specified in GB/T 6682.
A.1.4 Reference substance of 3-[(4-Amino-2,2-dioxo-1H-2,1,3-benzothiadiazine-5-yl)oxy]-2,2-dimethyl-N-propyl propionamide: Purity>=99.0%.
A.2 Apparatus
Ultra-high performance liquid chromatograph: Equipped with diode array detector.
A.3 Reference chromatographic conditions
A.3.1 Chromatographic column: C18 liquid chromatographic column; length is 100 mm; inner diameter is 4.6 mm; particle size is 3.5 µm; or other equivalent chromatographic columns.
A.3.2 Mobile phase: It consists of 0.1% formic acid solution (A.1.1.1) and acetonitrile (A.1.2) in a volume ratio of 8:2.
A.3.3 Column temperature: 25 °C.
A.3.4 Flow rate: 1.0 mL/min.
A.3.5 Injection volume: 1 µL.
A.3.6 Detection wavelength: 230 nm. […]
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This preview omits tables, figures, formulas and parts of the technical clauses. The complete document — 21 pages — is available in the English PDF.
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