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GB 1886.347-2021National food safety standard - Food additives -4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride (English PDF)

食品安全国家标准食品添加剂 4-氨基-5,6-二甲基噻吩并[2,3-d]嘧啶-2(1H)-酮盐酸盐

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Issued by

NHC; SAMR

Level / Type

National · Mandatory

Issue date

February 22, 2021

Implementation date

August 22, 2021

Scope

GB 1886.347-2021 is the English-translated version of 食品安全国家标准食品添加剂 4-氨基-5,6-二甲基噻吩并[2,3-d]嘧啶-2(1H)-酮盐酸盐.

GB 1886.347-2021 is the Chinese national food safety standard for the food additive 4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride, produced through chemical reaction from malononitrile, 3-mercapto-2-butanone and other raw materials.

It gives the chemical name, the molecular formula C8H9N3OS-HCl, the structural formula and the relative molecular mass 231.7, and fixes the sensory and technical requirements.

Appendix A sets out the determination of the content by ultra-high performance liquid chromatography with a diode array detector: the trifluoroacetic acid solutions and the chromatographically pure acetonitrile to prepare, the C18 column 100 mm long with an inner diameter of 4.6 mm and a particle size of 3.5 µm, the mobile phase, the column temperature of 30 °C, the flow rate and the detection wavelength of 245 nm. It was issued on 22 February 2021 and has applied since 22 August 2021.

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Document preview — GB 1886.347-2021

National Standard of the People's Republic of China

Issued by: NHC; SAMR

1 Scope3
2 Chemical name, molecular formula, structural formula, relative molecular mass3
3 Technical requirements3
Appendix A Determination of the content of 4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride5

1 Scope

This standard is applicable to food additives, 4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride, which are produced through chemical reaction, by the raw materials of malononitrile, 3-mercapto-2-butanone, etc.

2 Chemical name, molecular formula, structural formula, relative molecular mass

2.1 Chemical name

4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride

2.2 Molecular formula

C8H9N3OS·HCl

2.3 Structural formula

2.4 Relative molecular mass

231.7 (According to 2018 international relative atomic mass)

3 Technical requirements

3.1 Sensory requirements

Appendix A Determination of the content of 4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride

A.1 Reagents and materials

A.1.1 Trifluoroacetic acid: Purity >= 98%.

A.1.1.1 The 0.1% trifluoroacetic acid solution: Pipette 1.00 mL of trifluoroacetic acid (A.1.1). Add it to a 1000 mL volumetric flask. Add water (A.1.3) to dilute it to the mark. Shake well.

A.1.1.2 The 0.05% trifluoroacetic acid solution: Pipette 0.50 mL of trifluoroacetic acid (A.1.1). Add it to a 1000 mL volumetric flask. Add water (A.1.3) to dilute it to the mark. Shake well.

A.1.2 Acetonitrile: Chromatographically pure.

A.1.3 Water: Grade 1 water as specified in GB/T 6682.

A.1.4 Control product of 4-amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one hydrochloride: Purity >= 99.0%.

A.2 Instrument and equipment

Ultra-high performance liquid chromatograph: Equipped with a diode array detector.

A.3 Reference chromatographic conditions

A.3.1 Chromatographic column

C18 liquid chromatographic column, which has a length of 100 mm, an inner diameter of 4.6 mm, a particle size of 3.5 µm; OR other equivalent chromatographic column.

A.3.2 Mobile phase

Composed of 0.1% trifluoroacetic acid solution (A.1.1.1) and acetonitrile (A.1.2), in a volume ratio of 95:5.

A.3.3 Column temperature: 30 °C

A.3.4 Flow rate: 1.0 mL/min.

A.3.5 Injection volume: 1 µL

A.3.6 Detection wavelength: 245 nm

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This preview omits tables, figures, formulas and parts of the technical clauses. The complete document — 23 pages — is available in the English PDF.

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